The results of research on the methods of bronchopneumonia treatment of young cattle are presented. It is noted that the disease is associated with the effect of a number of different etiological conditions (lower air temperature, air humidification, and air pollution, etc.) on the animal's body. Bronchopneumonia of calves is registered at livestock complexes in cold and wet seasons as a seasonal disease. In this regard, the development of effective treatment schemes for this pathology is an urgent task. The effectiveness of the use of substitution therapy preparations in the treatment of bronchopneumonia of calves was studied. The study was conducted at a farm in the Altai Territory in the autumn period. For realization of this experiment two equal groups (experimental and control) of 5 calves in each were formed according to the principle of analogies. The treatment regimen for both groups included Resflor and Loxic 2% preparations. Calves of the control group received VitOkey as a substitution therapy, the experimental group – Vitam. Clinical signs and blood morphologic analysis were evaluated during the experiment. Clinical examination of the calves showed the following signs: elevated body temperature, wheezing, coughing, foci of blunting in the lungs in the anterior and posterior lobes, apathy, nasal discharge, loss of appetite, erythropenia (up to (4.6 ± 0.2) × 1012/l), leukocytosis (up to (16.5 ± 0.6) × 109/l), increased ECR (up to 1.2 ± 0.1 mm/h), neutrophilic leukocytosis with a leftward shift of the nucleus, and monocytopenia. By the 5th day of treatment, the calves of the experimental group had no pulmonary rales, coughing, and the body temperature was within normal limits. On the 7th day, there was an increase in erythrocytes ((6.4 ± 0.3) × 1012/l), a decrease in leukocytes ((10.6 ± 0.3) × 109/l) and ESR (0.4 ± 0.1 mm/h). The use of vitamin-amino acid complex in complex therapy of bronchopneumonia of calves reduces the duration and severity of the course of the disease.