SUBCHRONIC TOXICITY TESTING OF THE DRUG ARGOVIT ON LABORATORY ANIMALS

Abstract

Subchronic toxicity parameters of the silver-containing drug Argovit were determined in laboratory animals. The study was conducted on male and female outbred albino mice (n = 70) weighing 18.0-20.0 g, and male and female albino rats (n = 70) weighing 180.0-200.0 g. The drug was administered to white rats, and immunobiochemical investigations of their blood serum were conducted in 4th, 8th, 12th, 16th, 20th, 24th and 28th days after drug administration for determining total protein, glucose, cholesterol, total lipids, phosphorus, calcium, globulins (a, b, g). During 29 days, white mice (n = 10) and white rats (n = 20) of the control group were orally administered with 0.85% aqueous solution of sodium chloride at a dose equal to administered drug Argovit. In white mice, the cumulation coefficient (Kc) made up 24.15, in white rats 16.1, which allowed attributing the drug tested to non-cumulative ones. Long-term administration of increasing toxic doses of the drug Argovit to white rats did not result in true significant changes in immunobiochemical parameters of their blood serum. During the whole studying period, deaths of laboratory animals, as well as dysfunctions of their gastrointestinal tracts, were not revealed.