Studying a toxic effect of anthelminthics mixture on laboratory Animals

Abstract

There was studied the effect of anthelminthics mixture of Alben and Askazin on laboratory animals and birds. The experimental animals and birds divided into three groups were given these preparations mixed in different doses. The mixture of anthelminthics Alben and Askazin was administered in a therapeutic dose as well as in doubled and tripled doses, which had no adverse toxic effects on the organism of the laboratory animals and birds. With that, the general condition of the animals and birds remained unchanged. Clinical signs - body temperature, functions of cardiovascular and respiratory systems - varied within limits. Based on hematological studies conducted, there were not observed any pronounced deviations from the morphological parameters of blood and erythrocyte sedimentation rate. The contents of the levels of hemoglobin, red blood cells and white blood cells were within the physiological norm. After post-mortem autopsies of birds the pronounced changes in their gastro-intestinal tract and internal organs were not found. It has been found that the use of anthelminthics mixture of Alben and Askazin in therapeutic dose as well as in increased (doubled and tripled) doses has no adverse toxic effects on laboratory animals and birds.