Therapeutic efficacy of sulfogel at claw diseases in cows

Abstract

There was developed and tested a new complex medicinal preparation for local application, sulfogel, possessing high antimicrobic activity against Fusobacterium necrophorum and accompanying microflora at purulent-necrotic processes in the area of the extremities’ distal parts. Taking into account biological properties, antibiotic and drug resistance of this microflora, the preparation was concluded to be multi-component. The composition of the preparation includes such medicinal substances as antibiotics, sulfanilamides, antiseptic remedies, and formers. On-farm tests were carried out at the animal-breeding farms of Novosibirsk Region having a claw disease problem. Purulent- necrotic affections of claws in cattle at the dairy farms are widespread; their clinical manifestations are extremely various. Cattle claw trimming showed the following affections: flesh ulcer, nimbus phlegmon, interdigital phlegmon, Rusterholz’s ulcer, purulent inflammations of claw joints. By bacteriological examinations of the biomaterial taken from several sick animals were isolated the pathogenic isolates of the necrobacteriosis causative agent F. necrophorum. Based on clinical signs and laboratory investigations of the biomaterial, bovine necrobacteriosis and digital dermatitis were diagnosed. Sulfogel was applied locally after surgical treatment of wound surfaces of the claw. The preparation had no by-effects, and did not cause complications. The therapeutic efficacy of sulfogel was 100% with duration of treatment of 12-16 days in the scientific experiment, and that of necrogel was 83.3% with 16-20 days in the control group. During on-farm testing at the farms having a claw disease problem the therapeutic efficacy of sulfogel made up 94.34 ± 0.40% (p < 0.01), that of necrogel 85.07 ± 0.62%.