Application of drugs containing metal anoparticles in veterinary medicine

The analysis of nanotechnology development was carried out and the assessment of prospects of use of silver and bismuth nanoparticles in vetere-nary medicine was given. Modern development of animal husbandry is linked with diseases caused by conditionally pathogenic microflora. Treatment of these diseases is based on the use of a wide range of antibacterial substances, both in mono version and in a combined form. When used long-term, these antibacterial preparations cause the phenomenon of antibiotic resistance in bacteria. One way to solve this problem is by applying medication containing nanoparticles obtained by means of nanotechnology. Depending on the method of preparation, such medicinal substances can be both highly effective and highly toxic and have a wide range of previously unexplored properties, which necessitates the study of their toxicological and therapeutic properties. Silver nanoparticles are the most studied ones. They have pronounced antibacterial properties with low toxicity and no negative effect on the indigenous microflora of animals. Properties of nanoparticles also depend on the shape and size of the particles, which determines their scope and limitations. The main field of application of silver nanoparticles is the treatment of diseases caused by conditionally pathogenic microflora (mastitis, gastrointestinal and gynecological diseases). Bismuth preparations are used in the treatment of human ulcers. However, in the treatment of animals, the experience of their application is extremely limited. For treatment of gastrointestinal diseases, the preparations with nanoparticles of bismuth (Enterovis) as well as nanoparticles of silver (Argovit) were used. Enterovis was used in the form of 2.0% aqueous solution in the rate of 1.0-2.0 ml/kg of body weight 2-3 times a day, for 1-2 days, and Argovit was used in the form of 1.0% aqueous solution in the rate of 2.0-3.0 ml/kg of body weight 2-3 times a day, for 2-5 days. The survival rate of animals in the experimental group with the application of Enterovis and Argovit was 91.1 to 100%, with the term of treatment reduced by over 1.5-2 times. In control groups, where antibiotics were used, the survival rate of animals was 63.8-90.5%.

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