EFFICACY OF THE BIOLOGICALLY ACTIVE DRUG PANTOIN USED TO INCREASE IMMUNITY LEVEL
Abstract
Experimental data are given from a study of immunostimulatory properties of the drug Pantoin injected into the sport horse’s system. In the first experiment was studied the effect of Pantoin, administered intramuscularly in doses of 5 and 10 ml, on indices of natural resistance. The increase in all blood values in the experimental animals as compared with the control group’s horses was observed in 7 and 14 days after injections. In the second experiment was studied the effect of Pantoin on immunity of experimental horses to the equine rhinopneumonia virus, where the vaccine was administered simultaneously with 5 or 10 ml dose of Pantoin. The rhinopneumonia antibody titers in the blood serum of horses of all groups were measured before vaccination, and in 21, 28 and 35 days after. The antibody titers in the serum of the experimental animals were significantly higher (6.2 ± 0.25, and 7.9 ± 0.34) as compared with the control group’s horses (5.6 ± 0.13). The maximum effect was obtained, when Pantoin was used in a dose of 10 ml. The research results showed that the drug Pantoin can be used for both increasing natural resistance of horses and boosting immunity intensity during vaccination.
About the Authors
N. E. Panova
Institute of Experimental Veterinary Science of Siberia and the Far East, Russian Academy of Agricultural Sciences
Russian Federation
Russian Federation
O. A. Donchenko
Institute of Experimental Veterinary Science of Siberia and the Far East, Russian Academy of Agricultural Sciences
Russian Federation
Russian Federation
V. G. Shelepov
State Scientific Establishment Siberian Branch of the Russian Academy of Agricultural Sciences
Russian Federation
Russian Federation
E. V. Grishina
Institute of Experimental Veterinary Science of Siberia and the Far East, Russian Academy of Agricultural Sciences
Russian Federation
Russian Federation
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Review
For citations:
Panova N.E., Donchenko O.A., Shelepov V.G., Grishina E.V. EFFICACY OF THE BIOLOGICALLY ACTIVE DRUG PANTOIN USED TO INCREASE IMMUNITY LEVEL. Siberian Herald of Agricultural Science. 2014;(5):89-92. (In Russ.)
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