MIXING OF FODDER MASSES IN THE INTESTINES OF LABORATORY MICE AS INFLUENCED BY DRUGS MODULATING INTESTINAL MOTILITY
Abstract
The aim of the work was to study processes of mixing food masses in the intestines as a factor in maintaining the homeostasis of the microbiota of the intestines. Laboratory mice were administered the two fluorescent labels to the gastrointestinal tract, then the process of mixing fluorescent dyes with the intestinal contents was analyzed. It has been found that the liquid component of the intestinal mass has much more intense movements including those in the oral direction of the intestinal tube. Theoretically, if there is a local inflammation, the accumulation of fluid may results in dissemination of the inflammation source throughout the gastrointestinal tract. The mixing processes and the rate of excretion of fluorescent labels in the lumen of the intestines (as a component of feces) and in the edge zone of the intestinal tube differ significantly, and the dyes remain in the mucosa of the small intestine after 4-5 hours after administration.
About the Authors
V. N. Afonyushkin
Institute of Experimental Veterinary Science of Siberia and the Far East
Russian Federation
Russian Federation
M. L. Filipenko
Institute of Chemical Biology and Fundamental Medicine
Russian Federation
Russian Federation
V. YU. Koptev
Institute of Experimental Veterinary Science of Siberia and the Far East
Russian Federation
Russian Federation
M. A. Titova
Institute of Experimental Veterinary Science of Siberia and the Far East
Russian Federation
Russian Federation
S. A. Bolyakhina
Institute of Experimental Veterinary Science of Siberia and the Far East
Russian Federation
Russian Federation
V. S. Cherepushkina
Novosibirsk State Agrarian University
Russian Federation
Russian Federation
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Review
For citations:
Afonyushkin V.N., Filipenko M.L., Koptev V.Yu., Titova M.A., Bolyakhina S.A., Cherepushkina V.S. MIXING OF FODDER MASSES IN THE INTESTINES OF LABORATORY MICE AS INFLUENCED BY DRUGS MODULATING INTESTINAL MOTILITY. Siberian Herald of Agricultural Science. 2015;(1):81-89. (In Russ.)
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