ACUTE AND CHRONIC TOXICITY OF THE VETERINARY DRUG ARGUMISTIN

Abstract

The veterinary drug Argumistin is an aqueous colloidal solution of silver nanoparticles (10 mg/ml or 50 mg/ml) stabilized with benzyldimethyl[3-(myristoylamino)propyl]ammonium chloride monohydrate (0.01%). In this work we investigated acute and chronic toxicity of Argumistin in the form of aqueous solution for topical and internal use. According to the classification LD50, the veterinary drug Argumistin is referred to low-hazard substances, when intragastrically administered to laboratory animals (mice). Long-term enteral administration in doses of 5 ml/kg did not lead to a damaging effect on the performance status of white non-linear mice. In intragastric administration for 10 days in a dose of 45 ml/kg (100-fold excess of the recommended daily therapeutic dose), statistically significant changes in the mass of the liver and spleen, as well as changes in certain biochemical indices of blood, were registered.